Jiao Chun-l
2014
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Journal
Journal of Pharmaceutical Research
Abstract
Objective To synthesize 4-( 4,6- dimorpholino- 1,3,5- triazin- 2- yl) aniline. Methods 4,4'-( 6- chloro- 1,3,5- triazine- 2,4- diyl) dimorpholine was synthesized with 2,4,6- trichloro- 1,3,5- triazine and morpholine by substitution reaction under ice bath,and then reacting with amino- phenyl- 4- boronic acid pinacol ester to obtain 4-( 4,6- dimorpholino- 1,3,5- triazin- 2- yl) aniline by Suzuki reaction. Results and Conclusion The structure was confirmed by1H- NMR and ESI- MS,the overall yield was 61. 7%.