G. Auger, J. Heijenoort, D. Blanot
Sep 1, 2010
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Journal
Bulletin des Sociétés Chimiques Belges
Abstract
Two dipeptides containing antibacterial amino acids, 2-aminopimelic acid (Apm) and propargylglycine (Pra), were synthesized: L-Pra-ambo-Apm (1) and ambo-Apm-L-Pra (2). 1 was easily obtained from the protected derivative resulting from the coupling (carbodiimide method) of Boc-L-Pra-OH with H-ambo-Apm(OBu1)-OBu1. For 2, we followed a synthesis scheme in which the e-carboxyl group of Apm was unprotected: after the coupling of Boc-rac-Apm-N3 with H-L-Pra-OBu1, mild acidolytic treatment afforded the desired dipeptide. 2 displayed weak antibacterial activity against some species.