Bruna Á. Pereira, Alcione V. de Bastos, Wystan K O Teixeira
Aug 8, 2017
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Journal
Molecular Diversity
Abstract
An elegant, efficient, and highly regioselective approach for the synthesis of novel methyl 5-amino-3-(methylthio)-1-differently substituted-1H-pyrazole-4-carboxylates is reported. The procedure involves the cyclocondensation of $$\alpha $$α-oxeketene $$S,S$$S,S-dimethyl acetal building blocks with different alkyl, aryl, and heterocyclic acid hydrazides. The novel molecules were obtained in good yields and their identities confirmed by NMR and HRMS spectrometry.