S. Niwayama, Masoud Zabet-Moghaddam, S. Kurono
Oct 15, 2016
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Journal
Bioorganic & medicinal chemistry letters
Abstract
Ethyl succinic anhydride and its d5-labeled version have been synthesized and applied to quantitative analysis of peptides in combination with MALDI or ESI mass spectrometry. These modifiers react with amino groups in the N-termini and lysine side chains in proteins, and therefore the combination of these modifiers was shown to be a useful tool for quantification of peptides and hence for proteomics research.