G. Fleet, J. Son, D. Green
1988
Citations
0
Influential Citations
49
Citations
Journal
Tetrahedron
Abstract
Abstract The syntheses of 1,4-dideoxy-l,4-imino-L-ribitol and of 1,4-dideoxy-l,4-imino-D-talitol from D-mannose are described. 1,4-Dideoxy-l,4-imino-D-talitol is a specific and competitive inhibitor of human liver α-mannosidase in vitro and also blocks the lysosomal catabolism of asparigine-linked glycans of glycoproteins in vivo .