Lin Chun-xiang
2009
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0
Influential Citations
1
Citations
Journal
Chinese Journal of Pharmaceuticals
Abstract
Docetaxel was synthesized from 10-deacetylbaccatin Ⅲ by selective protection of the hydroxyl group to give 7,10-di-(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin Ⅲ,which was subjected to condensation with(4S,5R)-N-tert-butoxycarbonyl-2-(4-methoxy)phenyl-4-phenyl-1,3-oxazolidinyl-5-carboxylic acid and then deprotection with Zn/HCOOH in methanol with an overall yield of about 56%.