G. Mahanthesha, T. Suresh, T. R. R. Naik
2022
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Journal
Rasayan Journal of Chemistry
Abstract
A series of substituted 3-(3-chlorobenzoyl)-N-phenylindolizine-1-carboxamides have been synthesized from 3- chlorobenzoyl-indolizine-1-carboxylic acid with substituted aromatic amines in the presence of triethylamine and Pybop reagent. All the newly synthesized compounds were confirmed by Elemental, FTIR, 1H NMR, 13C NMR and Mass spectroscopic techniques. The obtained target compounds showed excellent in vitro anti-tuberculosis, anticancer, anti-inflammatory and antibacterial activity. Molecular docking studies have supported the in vitro anticancer activity of these molecules.