N. Aggarwal, K. Gopika, B. Revanasiddappa
May 25, 2022
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Journal
Research Journal of Chemistry and Environment
Abstract
A new series of 3,5-dimethyl-arylazopyrazoles (3a-h) was synthesized by reacting various oxobutyrates (2) with 4-methoxy benzhydrazide (1) in glacial acetic acid medium. The oxobutyrates were prepared by diazotization of substituted anilines and subsequent condensation with acetyl acetone in the alcohol medium. The new compounds were elucidated on the basis of IR, 1H-NMR and mass spectral data and the compounds were screened for their in vitro cytotoxic activity using MDA-MB-231 and MCF-7 cell lines. Some of the tested compounds showed weak to moderate cytotoxic effects.