V. Georgiyants, L. Perekhoda, N. Saidov
Apr 8, 2014
Citations
0
Influential Citations
3
Citations
Journal
European Chemical Bulletin
Abstract
A simple and efficient synthesis of 4-allyl-5-(4-R1)-phenoxythiomethyl-1,2,4-triazole-3-yl-mercaptoacetic acid derivatives 7a-l is described herein. This technique uses a direct alkylation 3-mercapto-4-allyl-5-(4-R1)-phenoxythiomethyl-1,2,4-triazoles 5a-b, with substituted chloracetic acid anilides 6a-k, and α-chloro-(4-bromo)-acetophenone 6l. The probability of anti-ulcer activity of the newly synthesized substances 5a-b and 7a-l was simulated by the computer program PASS and docking studies. The findings show that all substances of this group may be used for the treatment NSAID-inducеd ulcers.