Parvesh Singh, P. Sharma, Krishna. Bisetty
Jul 9, 2011
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0
Influential Citations
9
Citations
Journal
Arkivoc
Abstract
A series of new thiophene compounds 6a-6l was synthesized from the reactions of in situ generated cross-conjugated enaminothiones 2 and α-bromoketones/ethyl bromoacetate. Moreover, the synthesis of 1,3-thiazine 12 and functionalized thiopyran 18 heterocycles from the cycloaddition reactions of N,N’-bis[(dimethylamino)methylene]thiourea 9, is also described. Additionally, the binding conformations of these compounds 6a-6l and some anti-inflammatory drugs (NSAIDs) were determined by their docking in the active site of the Cyclooxygenase-2 (COX-2) enzyme.