Seylan Ayan, Ö. Doğan, Polina M Ivantcova
Jul 31, 2013
Citations
0
Influential Citations
15
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract The (2 R ,4 R ,5 S )- and (2 S ,4 S ,5 R )-enantiomers of 4-( tert -butyl) 2-methyl 5-(4-bromophenyl)-pyrrolidine-2,4-dicarboxylate 3 were synthesized efficiently with an ee of >90% on a gram scale using a FAM -catalytic methodology. Subsequent modification afforded enantiopure N -((4-chlorophenyl)thio)acetyl pyrrolidine derivatives 4 , which are potential thrombin inhibitors according to comprehensive molecular docking studies.