V. Shibaev, V. Veselovsky, A. Lozanova
Jan 17, 2000
Citations
0
Influential Citations
16
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Derivatives of dolichyl phosphate (Dol-P) with 2-aminopyridine or 1-aminonaphtalene fluorophore groups at the omega-end of the chain were synthesized. These products serve as substrates for recombinant yeast Dol-P-mannose synthase. Fluorescence resonance energy transfer between a Trp residue of the enzyme and the 1-aminonaphtalene group of the Dol-P analogue was demonstrated.