A. Horn, B. Kaptein, N. Vermue
Jul 1, 1988
Citations
1
Influential Citations
16
Citations
Journal
European Journal of Medicinal Chemistry
Abstract
Abstract The synthesis of N,N -dipropyl-8-hydroxy-3-chromanamine from 8-methoxy-4-chromanone oxime in seven steps is described. This compound is an oxygen isostere of the dopamine (DA) receptor agonist N,N -dipropyl-5-hydroxy-2-aminotetralin. In in vitro and in vivo tests of dopaminergic activity N,N -dipropyl-8-hydroxy-3-chromanamine was found to be a more potent DA agonist than apomorphine.