A. Fokin, A. G. Yurchenko, V. N. Rodionov
Sep 22, 2007
Citations
0
Influential Citations
24
Citations
Journal
Organic letters
Abstract
The antimalarial drug FR900098 was prepared from diethyl allylphosphonate involving the nitroso-ene reaction with nitrosocarbonyl methane as the key step followed by hydrogenation and dealkylation. The utilization of dibenzyl allylphosphonate as the starting compound allows one-step hydrogenation with dealkylation, which simplifies the preparative scheme further.