A. Kamal, G. Khanna, R. Ramu
Jun 16, 2003
Citations
1
Influential Citations
53
Citations
Journal
Tetrahedron Letters
Abstract
An efficient and facile chemoenzymatic synthesis of duloxetine by lipase mediated resolution of 3-hydroxy-3-(2-thienyl)propanenitrile has been achieved. This process also describes an enantioconvergent synthesis of duloxetine via a Mitsunobu reaction.