Shannon He, Xue Li, Jia-Ning Dai
2008
Citations
0
Influential Citations
8
Citations
Journal
Chinese Chemical Letters
Abstract
Abstract Antidepressant duloxetine ( 1 ) was prepared via asymmetric transfer hydrogenation of 3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one ( 3 ). The Ru(II), Rh(III) and Ir(III) complexes of several chiral ligands were examined as the catalyst and ( S , S )- N -tosyl-1,2-diphenyl ethylenediamine (TsDPEN)–Ru(II) complex was found to provide good yield and excellent enantioselectivity.