E. Owusu-Ansah, A. Durow, J. Harding
Jan 7, 2011
Citations
1
Influential Citations
12
Citations
Journal
Organic & biomolecular chemistry
Abstract
(S)-4,4-Dichloro-3-methylbutanoic acid was prepared in 51% overall yield from commercially available starting materials using an organocatalytic transfer hydrogenation to 4,4-dichloro-3-methylbut-2-enal in the key step. The (S)-dichloro acid was used as an intermediate in the first total synthesis of dysideaproline E and a diastereomer confirming the structure of the natural product.