Zhao Xing-ru
2007
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Efaproxiral was synthesized from p-hydroxyphenylacetic acid by condensation with 3,5-dimethyl-aniline to give N-(3,5-dimethylphenyl)-2-(4-hydroxyphenyl)acetamide, which was subjected to reaction with acetone, chloroform and 50% NaOH solution with an overall yield of about 61%.