P. Ferraboschi, S. Ciceri, P. Grisenti
Sep 30, 2013
Citations
0
Influential Citations
7
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract The synthetic antithrombotic argatroban is a dipeptide between the nonproteogenic (2 R ,4 R )-4-methyl-2-piperidine carboxylic acid and l -arginine, in turn bonded to a 3-methyltetrahydroquinoline sulfonyl group; the drug is usually prepared and administered as a mixture of C-21-diastereoisomers. By means of a biocatalytic transformation enantiomerically pure ( R )- and ( S )-synthons, suitable for the synthesis of separate (21 R )- and (21 S )- argatroban, were obtained.