L. Harwood, S. Tyler, M. Drew
Oct 11, 2000
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0
Influential Citations
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Journal
Arkivoc
Abstract
The imine moiety of (5S)-3-((2-methoxycarbonyl)ethyl)-5-phenyl-5,6-dihydro-2H-1,4- oxazin-2-one 2 undergoes highly diastereocontrolled reduction and Lewis acid-mediated chemo- and diastereoselective nucleophilic addition of Grignard reagents. Subsequent dismantling of the cyclic template permits ready access to enantiomerically pure glutamic acid analogues.