Yong‐Chul Jeong, S. Hwang, K. Ahn
2005
Citations
0
Influential Citations
3
Citations
Journal
Bulletin of The Korean Chemical Society
Abstract
Optically active 4-substituted pyrrolidin-2-one substructures can be found in various biologically active compounds such as CS-834, 1, an oral carbapenem antibiotic drug, rolipram, 2, an antidepressant agent and oxiracetame, 3, a nootropic drug for the Alzheimer’s disease. Chiral 4hydroxypyrrolidin-2-one and its N-substituted derivatives are versatile intermediates for the synthesis of those compounds. Therefore, several methods for the synthesis of optically active 4-hydroxypyrrolidin-2-one derivatives have been developed including methods using enzymatic reaction and multistep synthsis from a chiral natural intermediate. 7-12