Andreas S. Bommarius, Michael Schwarm, Klaus Stingl
1995
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0
Influential Citations
164
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Quality indicators
Journal
Tetrahedron-asymmetry
Abstract
Abstract Owing to its bulky, inflexible and hydrophobic tert -butyl side chain, tert -leucine (Tle) finds increased use in templates or catalysts in asymmetric synthesis as well as in peptidic medicinal compounds. ( S )-Tle, available through a large-scale enzymatic reductive amination process, has been incorporated into a variety of anti-AIDS and -cancer compounds. With two new routes to ( R )-Tle coming available, the number of applications of both ( R )- and ( S )-Tle can be expected to increase considerably.