Oh Kyoung Choi, B. Cho
Oct 1, 2000
Citations
0
Influential Citations
8
Citations
Journal
Organic Preparations and Procedures International
Abstract
Optically pure styrene oxide derivatives are important chiral building blocks for the synthesis of a variety of chiral drugs.' In particular, (R)-3-chlorostyrene oxide (1) is a key intermediate for the preparation of several 0,-adrenergic agonists that exhibit antiobesity and antidiabetic activities.! Several different methods for the synthesis of optically active (R)-1 have been reported. Asymmetric dihydroxylation of 3-chlorostyrene followed by chemical transformation to (R)-1 afforded 98% ee in good yield.?" Enzymatic resolution of racemic 3-chlorostyrene bromohydrin followed by the treatment of base' and hydrolytic kinetic resolution of racenuc 1 using salen catalyst' provide enantiomerically pure (R)-l.