Daqian Xu, K. Prasad, O. Repič
May 8, 1997
Citations
0
Influential Citations
30
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract A simple and practical method for large scale preparation of optically pure ethyl 2-amino-1-cyclohexanecarboxylate was developed via a reductive amination of 2-oxo-cyclohexanecarboxylate with a chiral α-methylbenzylamine. The major diastereomer was isolated in optically pure form by a simple and efficient crystallization as its HBr salt. The diastereoselectivity as well as the cis trans selectivity was also improved.