Jinyue Wu, Chen Liu, Yucheng Jiang
Mar 31, 2010
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Influential Citations
35
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Journal
Catalysis Communications
Abstract
Abstract Asymmetric epoxidation of 3-chloropropene can be catalyzed by chloroperoxidase (CPO) from Caldariomyces fumago to prepare ( R )-epichlorohydrin (ECH) in homogenous phosphate buffer/ionic liquid mixtures using t -butyl hydroperoxide (TBHP) as O 2 donor. Reaction conditions were optimized by the investigation of the choice of oxidants, the presence of ionic liquids (ILs), pH effect and CPO consumption. The best ECH yield reached 88.8% within a duration of 60 min with high enantiomeric excesses (e.e. 97.1%) at pH 5.5 and room temperature, using 1-ethyl-3-methylimidazolium [EMIM][Br] as co-solvent. The ILs with shorter carbon chain was more efficient on chiral ECH preparation.