M. A. Wijdeven, P. Botman, R. Wijtmans
Aug 9, 2005
Citations
0
Influential Citations
53
Citations
Journal
Organic letters
Abstract
The stereoselective total synthesis of the novel quinolizidine alkaloid (+)-epiquinamide is presented, starting from the amino acid l-allysine ethylene acetal. Key steps in the synthesis involved a highly diastereoselective N-acyliminium ion allylation and a ring-closing metathesis reaction to provide the bicyclic skeleton. [reaction: see text]