J. Min
2007
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Erlotinib hydrochloride was synthesized from methyl 3,4-dihydroxybenzoate by alkylation,nitration,reduction,cyclization,chlorination to give 4-chloro-6,7-bis-(2-methoxyethoxy)-quinazoline,which was subjected to amination with m-ethynylaniline and HCl salt formation with an overall yield of about 49%.