Sun Xiu-ling
2013
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Journal
Journal of Pharmaceutical Research
Abstract
Objective The synthesis of ertapenem sodium.Methods Ertapenem sodium was prepared from P-Nitrobenzyl(4R,5S,6S)-3-(diphenyloxy)phosphoryloxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclohept-2-ene-2-carboxylate(MAP)and 3-[(2S,4S)-4-Mercapto-pyrrolidine-2-carboxamido]benzoic acid hydrochloride(ertapenem side chain)as the raw materials,through the reaction of condensation,and then catalytic hydrogenation.Results The process had been successfully implemented to prepare the target compound in 67% overall yield and 99.3% area purity.Conclusion This process was more suitable for industrial production with simple operation,high purity and high yield.