Zhou Zhong-qiang
2005
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Journal
Chemical Reagents
Abstract
Trans-3-phenylglycidate ethyl ester was prepared from benzaldehyde and ethyl chloroacetate by Darzens condensation reaction. Ring-opening of trans-3-phenylglycidate ethyl ester with ammonium hydroxide provided the erythro-3-phenylisoser-ineamide. Benzoylation of erythro-3-phenylisoserineamide with PhCOCl furnished erythro- N-benzoyl-3-phenylisoserineamide which on treating with methanol gave the erythro-N-benzoyl-3-phenylisoserine methyl ester. Hydrolysis of the latter compound produced the title product.