X. Lan
2007
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Journal
Fine Chemical Intermediates
Abstract
Ethylamine hydrochloride as pesticide and pharmaceutical intermediates was synthesized through three step reactions.Hydroxylamine hydrochloride was contacted with acetone to give acetoxime then acetoxime was alkylated by diethyl sulfate to form O-ethylacetoxime,and finally,O-ethylacetoxime was hydrolyzed by hydrochloric acid to obtain ethylamine hydrochloride.The process of the reaction was optimized as follow:acetoxime reacted with diethyl sulfate for 6 h at 25℃ without catalyst to give O-ethylacetoxime with 87.6% of yield baseed on acetoxime.The total yield of product was 66.7% based on hydroxylamine hydrochloride.