P. Vemishetti, R. W. Leiby, E. Abushanab
Mar 1, 1988
Citations
0
Influential Citations
13
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
A practical and efficient synthesis of ethyl 1,2,4-triazole-3-carboxylate (6a, R' = H) from ethyl carboethoxyformimidate hydrochloride (7) is described. Alkylation of this heterocycle with the chloromethyl ethers of 1,3-O-dibenzylbutane-1,2R,3S-triol (8a) and 1,3,4-O-tribenzylbutane-1,2R,3S,4-tetrol (8b), followed by conversion of the ester function to the amide and deprotection, furnished the chiral 1′,2′-seco-nucleosides of ribavirin, 11a and 11b, respectively.