Zhou Yan-feng
2007
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Journal
Chinese Journal of Pharmaceuticals
Abstract
2,6-Dichloro-5-fluoronicotinic acid was treated with thionyl chloride in toluene to give 2,6-dichloro- 5-fluoronicotinoyl chloride, which was reacted with potassium ethyl malonate and magnesium chloride-triethylamine in ethyl acetate to give ethyl 2,6-dichloro-5-fluoronicotinoyl acetate with an overall yield of about 71%.