F. Fang
2011
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Journal
Applied Chemical Industry
Abstract
A practical and high-yield two-step procedure for the synthesis of ethyl 3-aminothiophene-2-carboxylate from mercaptoacetic acid and 2-chloroacrylonitrile through esterification and cyclocondensation was found and demonstrated.It was found that nonhygroscopic crystalline HCl salt of this amine provided a practical isolation point.The total yield in the two steps was 81%.