Hao Zhi-hui
2007
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Ethyl 4-(4-chlorophenyl)-3-methyl-2,4-dioxobutyrate, an intermediate of antiobesity agent rimonabant was synthesized from p-chloropropiophenone by enamination to give 4-[(Z)-1-(4-chlorophenyl)propenyl]morpholine, followed by condensation with chlorooxalic acid ethyl ester in 66% crude yield.