Y. Tamura, H. Choi, H. Shindo
Mar 25, 1982
Citations
0
Influential Citations
17
Citations
Journal
Chemical & Pharmaceutical Bulletin
Abstract
Friedel-Crafts reaction of aromatic compounds with ethyl α-chloro-α-(methylthio)-acetate (1) gave ethyl α-(methylthio) arylacetates (2), which were readily converted into ethyl arylacetates (3) by reductive desulfurization with Raney nickel or zinc dust-acetic acid. The reactions were applied to the syntheses of ibufenac (5) and alclofenac (6), which are anti-inflammatory agents.