Song Bao-an
2012
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Journal
Fine chemicals
Abstract
Ethyl 7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate was synthesized by Gould-Jacobs reaction under microwave-assistance using aluminium metal as catalyst.The optimum reaction conditions were ascertained by experiment program as follows:the microwave power was 160 W,the reaction temperature was 80 ℃,and the reaction time was 20 min,with Al being used as catalyst.The overall product yield was 94.2%.The structure of the product was determined by melting point measurements and NMR spectrometry that were applied to verify the target product.