Liang Gui-Jie
2011
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Journal
Chemistry & Bioengineering
Abstract
A novel compound ethyl 4-dimethylaminomethyl-5-hydroxy-1-methyl-6-nitro-2-phenylthiomethlindole-3-carboxylate was synthesized by using 1,4-benzoquinone and ethyl 3-(methylamino)-2-butenoate as raw materials,and via Nenitzescu reaction,O-acylation,nitration,bromination,condensation and Mannich reaction with an overall yield of 19.3%.The structures of synthesized intermediates and target compound were confirmed by 1HNMR and MS.