H. Ai
2006
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Ethyl methylaminothiazolyloximate was synthesized from ethyl 4-chloro-3-oxobutyrate by oximation and cyclization with thiourea to give ethyl 2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetate followed by etherification with (CH3) 2SO4 in presence of tetrabutylammonium bromide with an overall yield of 46%.