Zhu Qiu-feng
2005
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0
Influential Citations
1
Citations
Journal
Fine Chemical Intermediates
Abstract
Ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxo-propionate is the key of the synthesis of Quinolone antibacterial agents.2,6-dichloro-5-fluoro-nicotine acid was treated with Sulphurous oxychloride,to give 2,6-dichloro-5-fluoronicotinoyl chloride,then reacted to carbanion.The resultant was treated with p-Toluenesulfonic acid,to give the resultant we need.We improve on the reaction,using the cheap material,and selected the best one of the reagent to give the best of the resultant with nicer crystal.