X. Ji
2003
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Journal
Journal of China Pharmaceutical University
Abstract
AIM:Ethyl(3R,4R,5S)-4,5-epox y-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate is a key intermediate f or the preparation of novel anti-influenza drug oseltamivir and this study is to improve the chiral synthetic procedure of i t. METHOD:Title compound was stereoselectively prepared via a 6 -s tep reactions using(-)shikimic acid as starting material. RESULT: Its chemical structure was verified by FT-IR, 1 HNMR and 13 CNMR . CONCLUSION:Compared with the reported procedur e,this synthetic procedure is milder,an d has higher yield and lower cost.