Cheng Qing-rong
2007
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Journal
Chemistry World
Abstract
Ethyl demethylaminothiazolyloximate is one of the important medical intermediates,which forms side chains of semisynthetic cephalosporins.It was synthesized with ethyl 4-chloroacetate as raw material,and a sequential combined process of continuous adding reactants to carry out oximation and cyclocondensation in one reactor was used.The total yield was 91%.The technology not only eliminates the use of large quantity of organic solvents but also simplifies operation and shortens total reaction time.