Liao Qing-jiang
2004
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Journal
Chinese New Drugs Journal
Abstract
Objective:To synthesize etofibarte. Methods:Etofibrate was synthesized by reaction of sodium nicotinate and 2-[2-(4-chlorophenoxy)-2-methyl-propionyloxy] ethyl-chloride. The latter was obtained from 2-(4-chlorophenoxy)-2-methyl-propionic acid by esterifcation with glycol at first and then reacted with thionyl chloride. Results: The chemical structure of the target compound was confirmed by IR,1H-NMR,MS and element analysis. Conclusion: Etofibrate is conveniently synthesized using this route with a total yield of 53 % .