F. Carroll, F. Hauser, R. C. Huffman
Apr 1, 1978
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
Journal of medicinal chemistry
Abstract
Three 10-oxa-11-deoxyprostaglandin E1 and two 10-nor-9,11-secoprostaglandin F1 analogues were prepared. The compounds were evaluated for pregnancy interruptions, oxytocin-like activity (uterine strip), and antiprostaglandin activity. One of the 10-nor-9,11-secoprostaglandin F1 analogues displayed activity as a PGE2 antagonist in the gerbil colon smooth muscle preparation.