A. Bayoumi, Adel H. Ghiaty, A. El-Morsy
Dec 1, 2012
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Influential Citations
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Bulletin of Faculty of Pharmacy, Cairo University
Abstract
Abstract This study involves the synthesis and anticonvulsant evaluation of 1-ethyl-3-hydrazinylquinoxalin-2-1 H -one ( 8 ), and many other newly synthesized compounds ( 9 – 14 ). The structure of the synthesized compounds was confirmed by elemental analysis and spectral data (IR, 1 H NMR and Mass). Docking studies were performed to all the synthesized compounds in order to rationalize the anticonvulsant activity of the proposed compounds in a qualitative way. There is a strong correlation between the results of molecular modeling and the anticonvulsant activity of the synthesized compounds. The highest fitting value was noticed for compounds 9 and 10 “which showed the highest anticonvulsant activity”. Download full-size image