S. Gu, J. Lee, A. Pae
May 1, 2010
Citations
0
Influential Citations
19
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
We have synthesized and biologically evaluated 1,4-diazepane derivatives as T-type calcium channel blockers. In this study, we discovered compound 4s, a potential T-type calcium channel blocker with good selectivity over hERG and N-type calcium channels. In addition, it exhibited favorable pharmacokinetic characteristics for further investigation of T-type calcium channel related diseases.