M. J. Kornet, W. Beaven, T. Varia
Jul 1, 1985
Citations
0
Influential Citations
7
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
1-Amino-2-benzimidazolinones containing alkyl substituents on the amino nitrogen have been prepared by the sodium bis (2-methoxyethoxy)aluminum hydride reduction of 1-acylamino-2-benzimidazolinones. The latter compounds were obtained in two steps from o-nitro-β-acylphenylhydrazines. All of the 1-amino-2-benzimidazolinones exhibited activity in the standard anticonvulsant tests except for the 1-benzylamino compound. The most active compound was 1-ethylamino-2-benzimidazolinone which protected mice in the maximal electroshock seizure test at 30 mg/kg.