S. Rani
2012
Citations
0
Influential Citations
3
Citations
Journal
IOSR Journal of Applied Chemistry
Abstract
The reaction of 2-aryl-1H-indole-3-carboxaldehydes with substituted acetophenones in ethylene glycol and piperidine as a base gives the indole chalcones[4a-4f].Which on subsequent treatment with hydroxylamine hydrochloride in presence of base resulted in the cyclization of α, β-unsaturated ketone into the title compound [5a-5f] in 60-70% yield after column purification. The purity of the compounds was checked by TLC in ethylacetate: hexane (3:7). The structures of the all the compounds were established by H NMR, IR, LCMS and elemental analysis. The synthesized compounds [5a-5f] were evaluated for their anti-inflammatory activity.