G. Mariappan, R. Hazarika, Faruk Alam
Sep 1, 2015
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Journal
Arabian Journal of Chemistry
Abstract
Abstract A novel series of 2-substituted benzimidazole derivatives ( 3a – 3j ) were synthesized by the reaction of 2-chloro methyl benzimidazole with substituted primary aromatic amines. All the compounds were characterized by UV, IR, 1 H NMR, mass spectral data and CHN elemental analysis. The synthesized derivatives were screened for analgesic and anti-inflammatory activities. All the compounds showed significant effect at 100 mg/kg p.o. and the experimental data are statistically significant at p