N. Gautam, Abhilas Yadav, N. Khandelwal
Feb 28, 2014
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Journal
Journal of Chemical Sciences
Abstract
AbstractA series of novel fluorinated 10H-phenothiazines were synthesized via Smiles rearrangement. 10H-phenothiazines on refluxing with 30% hydrogen peroxide in glacial acetic acid gave 10H-phenothiazines-5, 5-dioxides (sulphones). These synthesized 10H-phenothiazines were then used as base to prepare ribofuranosides by treating them with sugar ( β-D-ribofuranosyl- 1-acetate-2, 3, 5-tribenzoate). The synthesized compounds were screened for antimicrobial activity and anthelmintic activity. The structural assignments of compounds were made on the basis of spectroscopic data and elemental analysis. Figure10H-phenothiazines were prepared by Smiles rearrangement. These prepared phenothiazines were used as a base to prepare ribofuranosides by treating with β-D-ribofuranose-1-acetate-2, 3, 5-tribenzoate. The structures of the synthesized compounds have been established by elemental analysis and spectroscopic data. The synthesized compounds were evaluated for their antimicrobial and anthelmintic activity.