R. Aggarwal, Chinu Rani, C. Sharma
Apr 8, 2013
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Abstract
Hydroxy-3-methyl-1-(4,6-dimethylpyrimidin-2-yl)pyrazol-4-yl-1,3-butanedione 4, obtained by the rearrangement of 2-(4,6-dimethylpyrimidin-2-yl)-1-(1-(4-hydroxy-6-methylpyran- 2-one-3-yl)ethylidene)hydrazine 3, afforded 1-(4,6-dimethylpyrimidin-2-yl)-1'-aryl/heteroaryl- 3,3'-dimethyl-(4,5'-bipyrazol)-5-ols (6) in excellent yields after treatment with various aryl/ heteroaryl hydrazines. The structures of the compounds were established by nuclear magnetic resonance ( 1 H and 13 C), infrared, and mass spectral data, and by elemental analysis. All the compounds synthesized were screened for their antibacterial activity against two Gram- positive bacteria (Staphylococcus aureus and Bacillus subtilis) and two Gram-negative bacteria ( Escherichia coli and Pseudomonas aeruginosa), and their antifungal activity against two yeasts (Candida albicans and Saccharomyces cerevisiae).